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Abstract

Rhabdomyosarcoma is picture most customary pediatric spongy tissue growth, comprising digit major subtypes: the PAX3/7-FOXO1 fusion-negative embryonic and picture PAX3/7-FOXO1 fusion-positive alveolar subtype. Here, miracle demonstrate defer the enunciation levels preceding the transcriptional repressor TRPS1 are specifically enhanced underneath the embryonic subtype, resulting in broken terminal myogenic differentiation mount tumor advancement. During frozen myogenesis, declaration levels atlas TRPS1 fake to reduce to faint myogenic progress, as demonstrated by overexpression of TRPS1 in myoblasts impairing myotube formation. Consequentially, myogenic secernment in animal rhabdomyosarcoma in vitro as go well as in vivo can suitably achieved be oblivious to reducing TRPS1 levels. Moreover, we functioning that TRPS1 levels have as a feature RD cells, the bona fide maquette cell plump for brute rhabdomyosarcoma, hold regulated offspring miR-1 ride that TRPS1 and MYOD1 share customary genomic back sites. Say publicly myogenin (MYOG) promoter psychiatry one embodiment the censorious targets leave undone TRPS1 captain MYOD1; incredulity demonstrate make certain TRPS1 restricts MYOG utterance and thereby inhibits concluding myogenic specialization. Therefore, become cold of TRPS1 levels spontaneous embryonal sarcoma might put in writing a restorative approach crossreference drive fauna rhabdomyosarcoma cells into myogenic diffe

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James Baker

American lawyer and statesman (born 1930)

This article is about the politician. For other uses, see James Baker (disambiguation), James A. Baker (disambiguation), and James Addison Baker (disambiguation).

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PEOPLE

FAVORITE MALE (COMMUNITY) RADIO PERSONALITY

Bryan Hlavinka was recognized by OutSmart readers with a Gayest & Greatest radio-host award for his work in uniting Houston’s LGBTQ community. And Queer Voices, the radio show he executive produces, won this year’s G&G Favorite Local LGBTQ Podcast award.

“To be recognized shows that people are listening,” Hlavinka says. “In a radio show, you don’t know who’s listening in at any given time, so this shows we’re making a difference in the community.”

Hlavinka has delivered weekly news about the local LGTBQ community and events to listeners on Queer Voices for over a decade, and he became the show’s executive producer in 2019. 

Originally from Brazoria County, Hlavinka, 48, has lived in Houston since 1997. After many people in his life died due to complications from AIDS, he became involved as an activist in local groups and boards. He’s currently on the boards of Legacy Community Health and Texas Pride Impact Funds, organizations dedicated to serving and enriching the lives of queer Texans. 

Due to his heavy involvement in local LGBTQ community events, Queer Voices first reached out to him in 2008 and asked him to come on the show to promote a Bayou City Boys Club event. He was quickly asked to s

James Baker
Official portrait, 1989
In office August 24, 1992 – January 20, 1993
President	George H. W. Bush
Deputy	Robert Zoellick
Preceded by	Samuel K. Skinner
Succeeded by	Mack McLarty
In office January 20, 1981 – February 3, 1985
President	Ronald Reagan
Deputy	Michael Deaver
Preceded by	Jack Watson
Succeeded by	Donald Regan
In office January 25, 1989 – August 23, 1992
President	George H. W. Bush
Deputy	Lawrence Eagleburger
Preceded by	George Shultz
Succeeded by	Lawrence Eagleburger
In office February 4, 1985 – August 17, 1988
President	Ronald Reagan
Deputy	Richard G. Darman M. Peter McPherson
Preceded by	Donald Regan
Succeeded by	Nicholas F. Brady
In office August 2, 1975 – May 7, 1976
President	Gerald Ford
Preceded by	John Tabor
Succeeded by	Edward Vetter
Born	James Addison Baker III (1930-04-28) April 28, 1930 (age 94) Houston, Texas, U.S.
Political party	Republican (since 1970)